Oral/tablet medications

Metformin

Metformin is a tablet that works by helping your body use insulin more effectively, so that it can properly use the glucose in your blood. Some people may find starting metformin causes stomach upsets, indigestion, and loss of appetite – starting at a low dose and taking the tablets with food can help this. Metformin does not cause hypoglycaemia (low blood glucose) and does not cause weight gain. It is also available in slow release form, known as prolonged/modified release.

Metformin is broken down by your kidneys. There is a common misconception that metformin damages kidneys, which it does not. However, if your kidneys are not working well (including dehydration) metformin cannot be broken down efficiently and tends to accumulate.

If you are ill with diarrhoea and vomiting, Metformin may need to be stopped temporarily until you are back to eating and drinking normally – get in touch with your GP or diabetes care team if you’re affected by this.

Sulphonylureas (glibenclamide)

Sulphonylureas are tablets that stimulate your pancreas (the organ in the abdomen that makes the hormone insulin) to produce more insulin, which will then lower your blood glucose levels. Sulphonylureas may cause mild indigestion, headache, skin rashes and weight gain. They can make your face flush if you drink alcohol. Because they increase insulin production, they can cause blood glucose levels to go too low.   Sulphonylureas are usually not prescribed during pregnancy, but glibenclamide is very occasionally used for gestational diabetes.

What if I forget a tablet?

If you remember a forgotten tablet within an hour or two, take it then. If it has been longer, miss that dose and take your next one as usual. Never double your dose because you have missed a dose.